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</div> <div class="container-fluid clearfix layout_564394 text-center text-bold" style="font-size: 20px; color: rgb(0, 0, 0); margin-top: 30px; margin-bottom: 15px;"> <div class="column"> <div class="container clearfix layout_439253"> <div class="column"> <div class="column visual-conent-title"> <p class="content-title"> 大脑创伤外泌体中环状RNA变化的研究</p> <div class="clearfix"> </div> </div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_610181" style="margin-top: 0px;"> <div class="column"> <div class="container clearfix layout_148235 text-center text-bold" style="font-size: 20px; color: rgb(0, 0, 0);"> <div class="column"> <div class="hr"> </div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_369638 text-center" style="margin-top: 15px; margin-bottom: 15px;"> <div class="column"> <div class="container clearfix layout_13448"> <div class="column"> <div class="col-md-12 layout_455380"> <div class="col-md-2 column"> </div> <div class="col-md-8 column"> <div class="column visual-conent-author visual-inline-block"> <p class="content-author"> <span>作者：</span>admin</p> </div> <div class="column visual-conent-adddate visual-inline-block" style="padding-left: 15px; padding-right: 15px;"> <p class="content-adddate"> <span>添加时间：</span>2019-04-15 13:22:22</p> </div> <div class="column visual-conent-source visual-inline-block"> <p class="content-source"> <span>来源：</span>云序生物</p> </div> <div class="column visual-category-statistics visual-inline-block" style="padding-left: 15px;"> 浏览：<script src="/index.php?case=archive&act=view_js&aid=32"></script></div> </div> <div class="col-md-2 column"> </div> </div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_617573" style="margin-top: 15px; margin-bottom: 15px;"> <div class="column"> <div class="container clearfix layout_903271"> <div class="column"> <div class="column visual-category-title"> <div class="content_tools_box"> <p class="content_tools"> <a href="javascript:CallPrint('print');">打印本文</a> <a href="javascript:doZoom(14)">小</a> <a href="javascript:doZoom(18)">中</a> <a href="javascript:doZoom(20)">大</a> </p> <div class="clearfix"> </div> </div> </div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_43304" style="margin-top: 15px; margin-bottom: 15px;"> <div class="column"> <div class="container clearfix layout_784828"> <div class="column"> <div class="column visual-conent"> <p><strong>题目</strong>：Circular RNA expression alteration in exosomes from the brain extracellular space after traumatic brain injury in mice</p><p><strong>期刊</strong>：Journal of Neurotrauma</p><p><strong>影响因子</strong>：5.19</p><p><strong>简介</strong>：近期，天津医科大学总医院张建宁教授带领的神经创伤团队针对大脑创伤的研究。应用全转录组测序技术，仅通过大脑创伤外泌体中环状RNA表达谱研究发表了世界首个小鼠脑创伤模型外泌体环状RNA研究成果。作者首先分离了小鼠脑组织，提取脑周质外泌体，通过外泌体全转录组测序检测TBI脑周组织外泌体中环状RNA的表达变化。结果发现231个差异表达的环状RNA，其中155个上调，76个下调。接下来通过生信分析如GO及KEGG分析对外泌体差异表达的环状RNA进行了功能预测。GO分析表明这些RNA分子主要参与神经损伤修复，神经系统发育及神经信号传导相关，这些分子同时主要富集在cGMP-PKG信号通路。环状RNA-miRNA互作网络图揭示了环状RNA作用靶miRNA及可能的功能。本文首次研究了大脑创伤外泌体中环状RNA变化，为后续分子机理详细研究提供诸多靶分子，也为大脑创伤的干预治疗提供潜在的靶点。</p><p style="text-align: center;"><img src="/html/upload/images/201904/15563520612302.jpg" width="583" height="309"/></p><p style="text-align: center;"><img src="/html/upload/images/201904/15563520865966.jpg" width="529" height="330"/></p></div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_676599" style="margin-top: 15px; margin-bottom: 15px;"> <div class="column"> <div class="container clearfix layout_158624"> <div class="column"> <div class="hr"> </div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_667472"> <div class="column"> <div class="container clearfix layout_381979"> <div class="column"> <div class=" visual-conent-form"> </div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_886423" style="margin-top: 15px; margin-bottom: 5px;"> <div class="column"> <div class="container clearfix layout_390441"> <div class="column"> <div class="column visual-conent-page"> <div id="page"> <strong>上一篇</strong><a href="/index.php?case=archive&act=show&aid=31">脂肪组织巨噬细胞分泌外泌体 miRNA可大幅改善体内胰岛素敏感性</a> <div class="blank10"> </div> <strong>下一篇</strong><a href="/index.php?case=archive&act=show&aid=33">外泌体LncRNA促进肿瘤细胞耐药性</a> </div> </div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_402892" style="margin-top: 15px; margin-bottom: 15px;"> <div class="column"> <div class="container clearfix layout_939884"> <div class="column"> <div class="hr"> </div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_57479" style="margin-top: 15px; margin-bottom: 15px;"> <div class="column"> <div class="container clearfix layout_608164"> <div class="column"> <div class="column visual-conent-comment"> </div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_815628" style="margin-top: 15px; margin-bottom: 15px;"> <div class="column"> <div class="container clearfix layout_771703"> <div class="column"> <div class="hr"> </div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_275539" style="margin-top: 15px; margin-bottom: 15px;"> <div class="column"> <div class="container clearfix layout_875600"> <div class="column"> <div class="column visual-conent-relevant-list"> <h3> <a><small>相关内容</small></a> </h3> <span>——</span> <hr class="featurette-divider" /> <div class="container list-container"> <div class="news-list list-border list-border-w"> <div class="list-date"> <span>15</span> <p> 2019-04</p> </div> <h4> <a title="大脑创伤外泌体中环状RNA变化的研究" href="/index.php?case=archive&act=show&aid=32" target="_blank">大脑创伤外泌体中环状RNA变化的研究</a> </h4> <p> 近期，天津医科大学总医院张建宁教授带领的神经创伤团队针对大脑创伤的研究，应用全转录组测序技术，仅通过大脑创伤外泌体中环状RNA表达谱研究发表了世界首个小鼠脑创伤模型外泌体环状RNA研究成果。… <a href="/index.php?case=archive&act=show&aid=32" target="_blank">[了解更多]</a> </p> </div> </div> <div class="clearfix"> </div> </div> </div> </div> </div> </div> </div> <div class="view-html"> <div class="container-fluid clearfix layout_971667" style="padding-top: 60px; padding-bottom: 60px; background-color: rgb(51, 51, 51); color: rgb(255, 255, 255);"> <div class="column"> <div class="container clearfix layout_976890 text-bold" style="font-size: 20px; padding-top: 20px; padding-bottom: 20px;"> <div class="column"> 厦门恩赛尔生物科技有限公司位于国家级企业孵化基地海沧生物医药产业园，参照GMP标准建设有完善的研发生产实验室并通过厦门市食品药品质量检查研究院依据国家标准GB50457-2008的洁净级别检测，团队汇聚大帮技术精湛的博士、硕士人员及外籍科学家，并由多名“千人计划”专家作为技术顾问，同时兼具遗传咨询师、系统架构师、注册审核员等各类人才，具备专业的科学研究和服务咨询能力。 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placeholder="请输入查询信息！"> <span class="input-group-btn"> <button class="btn btn-default" name='submit' type="submit">搜索</button> </span> </div> </div> <div class="col-lg-1"></div> </form> </div> </div> </div> </div> <!-- search end --> <!-- shopping 购物车 --> <div class="modal fade bs-example-modal-lg-shopping" tabindex="-1" role="dialog" aria-labelledby="mySmallModalLabel"> <div class="modal-dialog modal-sm"> <div class="modal-content"> </div> </div> </div> <!-- s/shopping 购物车 --> <div class="servers"> <!--[if (gte IE 7)|!(IE)]><!--> <!-- 在线客服 --> <style type="text/css"> .izl-rmenu{position:fixed; left:0; margin-right:20px; bottom:0px; padding-bottom:0px; z-index:999; } .izl-rmenu .sbtn{width:72px; height:73px; margin-bottom:1px; cursor:pointer; position:relative;} .izl-rmenu .btn-qq{background:url(/template/default_visual/skin/images/servers/metro_color/r_qq.png) 0px 0px no-repeat; background-color:#999;color:#FFF;} .izl-rmenu .btn-qq:hover{background-color:#444;color:#FFF;} .izl-rmenu 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.btn-ali{background:url(/template/default_visual/skin/images/servers/metro_color/r_ali.png) 0px 0px no-repeat; background-color:#999;} .izl-rmenu .btn-ali:hover{background-color:#444;} .izl-rmenu a.btn-ali,.izl-rmenu a.btn-ali:visited{background:url(/template/default_visual/skin/images/servers/metro_color/r_ali.png) 0px 0px no-repeat; background-color:#999; text-decoration:none; display:block;} .izl-rmenu .btn-wangwang{background:url(/template/default_visual/skin/images/servers/metro_color/r_wangwang.png) 0px 0px no-repeat; background-color:#999;} .izl-rmenu .btn-wangwang:hover{background-color:#444;} .izl-rmenu a.btn-wangwang,.izl-rmenu a.btn-wangwang:visited{background:url(/template/default_visual/skin/images/servers/metro_color/r_wangwang.png) 0px 0px no-repeat; background-color:#999; text-decoration:none; display:block;} .izl-rmenu .btn-skype{background:url(/template/default_visual/skin/images/servers/metro_color/r_skype.png) 0px 0px no-repeat; background-color:#999;} .izl-rmenu .btn-skype:hover{background-color:#444;} .izl-rmenu a.btn-skype,.izl-rmenu a.btn-skype:visited{background:url(/template/default_visual/skin/images/servers/metro_color/r_skype.png) 0px 0px no-repeat; background-color:#999; text-decoration:none; display:block;} .izl-rmenu .btn-web{background:url(/template/default_visual/skin/images/servers/metro_color/r_web.png) 0px 0px no-repeat; background-color:#999;} .izl-rmenu .btn-web:hover{background-color:#444;} .izl-rmenu a.btn-web,.izl-rmenu a.btn-web:visited{background:url(/template/default_visual/skin/images/servers/metro_color/r_web.png) 0px 0px no-repeat; background-color:#999; text-decoration:none; display:block;} .izl-rmenu .btn-top{background:url(/template/default_visual/skin/images/servers/metro_color/r_top.png) 0px 0px no-repeat; background-color:#999; display:none;} .izl-rmenu .btn-top:hover{background-color:#444;} </style> <script language="javascript" type="text/javascript"> $(function(){ var tophtml="<div id=\"izl_rmenu\" class=\"izl-rmenu\"><div class=\"sbtn btn-qq\"><div class=\"qq\"><a rel=\"nofollow\" target=\"_blank\" href=\"tencent://Message/?Uin=226976731&websiteName=http://www.ncell.com.cn=&Menu=yes\">客服一</a><br /><a rel=\"nofollow\" target=\"_blank\" href=\"tencent://Message/?Uin=525274299&websiteName=http://www.ncell.com.cn=&Menu=yes\">客服二</a></div></div><div class=\"sbtn btn-wx\"><img class=\"pic\" src=\"/html/upload/images/201904/15565910929476.png\" onclick=\"window.location.href=\'http:\'\"/></div><div class=\"sbtn btn-phone\"><div class=\"phone\">0592-5792117</div></div><div class=\"sbtn btn-top\"></div></div>"; $("#top").html(tophtml); $("#izl_rmenu").each(function(){ $(this).find(".btn-qq").mouseenter(function(){ $(this).find(".qq").fadeIn("fast"); }); $(this).find(".btn-qq").mouseleave(function(){ $(this).find(".qq").fadeOut("fast"); }); $(this).find(".btn-wx").mouseenter(function(){ $(this).find(".pic").fadeIn("fast"); }); $(this).find(".btn-wx").mouseleave(function(){ $(this).find(".pic").fadeOut("fast"); }); $(this).find(".btn-phone").mouseenter(function(){ $(this).find(".phone").fadeIn("fast"); }); $(this).find(".btn-phone").mouseleave(function(){ $(this).find(".phone").fadeOut("fast"); }); $(this).find(".btn-top").click(function(){ $("html, body").animate({ "scroll-top":0 },"fast"); }); }); var lastRmenuStatus=false; $(window).scroll(function(){//bug var _top=$(window).scrollTop(); if(_top>200){ $("#izl_rmenu").data("expanded",true); }else{ $("#izl_rmenu").data("expanded",false); } if($("#izl_rmenu").data("expanded")!=lastRmenuStatus){ lastRmenuStatus=$("#izl_rmenu").data("expanded"); if(lastRmenuStatus){ $("#izl_rmenu .btn-top").slideDown(); }else{ $("#izl_rmenu .btn-top").slideUp(); } } }); }); </script> <div id="top"></div><![endif]--> <!-- 短信 --> </div> <div class="servers-wap"> <link href="/template/default_visual/skin/css/wap/wap6.css" rel="stylesheet" /> <style type="text/css"> #plug-wrap { position: fixed; top: 0; left: 0; width: 100%; height: 100%; background: rgba(0, 0, 0, 0); z-index:800; } .top_bar { position:fixed; bottom:0; right:0px; z-index:900; -webkit-tap-highlight-color: rgba(0, 0, 0, 0); font-family: Helvetica, Tahoma, Arial, Microsoft YaHei, sans-serif; } .plug-menu { -webkit-appearance:button; display:inline-block; width:36px; height:36px; border-radius:36px; position: absolute; bottom:17px; right: 17px; z-index:999; box-shadow: 0 0 0 4px #FFFFFF, 0 2px 5px 4px rgba(0, 0, 0, 0.25); -webkit-transition: -webkit-transform 200ms; -webkit-transform:rotate(1deg); color:#fff; background-image:url('/template/default_visual/skin/images/wao/plug.png'); background-repeat: no-repeat; -webkit-background-size: 80% auto; background-size: 80% auto; background-position: center center; } .plug-menu:before { font-size:20px; margin:9px 0 0 9px; } .plug-menu:checked { -webkit-transform:rotate(135deg); } .top_menu>li { width: 32px; height:32px; border-radius:32px; box-shadow: 0 0 0 3px #FFFFFF, 0 2px 5px 3px rgba(0, 0, 0, 0.25); position:absolute; bottom:0; right:0; margin-bottom: 20px; margin-right:20px; z-index:900; -webkit-transition: -webkit-transform 200ms; } .top_menu>li a { color:#fff; font-size:20px; display: block; height: 100%; line-height: 33px; text-align: center; } .top_menu>li>a label{ display:none; } .top_menu>li a img { display: block; width: 22px; height: 22px; text-indent: -999px; position: absolute; top: 50%; left: 50%; margin-top: -11px; margin-left: -11px; } .top_menu>li.on:nth-of-type(1) { -webkit-transform: translate(-0, -100px) rotate(720deg); } .top_menu>li.on:nth-of-type(2) { -webkit-transform: translate(-47px, -81px) rotate(720deg); } .top_menu>li.on:nth-of-type(3) { -webkit-transform: translate(-81px, -45px) rotate(720deg); } .top_menu>li.on:nth-of-type(4) { -webkit-transform: translate(-100px, 0) rotate(720deg); } #sharemcover { position: fixed; top: 0; left: 0; width: 100%; height: 100%; background: rgba(0, 0, 0, 0.7); display: none; z-index: 20000; } #sharemcover img { position: fixed; right: 18px; top: 5px; width: 260px; height: 180px; z-index: 20001; border:0; } </style> <div class="top_bar" style="-webkit-transform:translate3d(0,0,0)"> <nav> <ul id="top_menu" class="top_menu"> <input type="checkbox" id="plug-btn" class="plug-menu themeStyle" style="background-image:url('/template/default_visual/skin/images/wap/plug.png');border:0px;"> <li class="themeStyle out" style="background:"> <a href="tel:0592-5792117"><img src="/template/default_visual/skin/images/wap/plugmenu1.png"><label>电 话</label></a> </li> <li class="themeStyle out" style="background:"> <a href="sms:13599994885"><img src="/template/default_visual/skin/images/wap/plugmenu3.png"><label>短信</label></a> </li> <li class="themeStyle out" style="background:"> <a href="mqqwpa://im/chat?chat_type=wpa&uin=226976731&version=1&src_type=web&web_src=http://www.ncell.com.cn" id="btn_fenxiang"><img src="/template/default_visual/skin/images/wap/plugmenu5.png"><label>QQ号码</label></a> </li> <li class="themeStyle out" style="background:"> <a href="/index.php?case=guestbook&act=index"><img src="/template/default_visual/skin/images/wap/plugmenu6.png"><label>留言</label></a> </li> </ul> </nav> </div> <div id="plug-wrap" style="display: none;" ></div> <script> $(function(){ $(".plug-menu").click(function(){ var li = $(this).parents('ul').find('li'); if(li.attr("class") == "themeStyle on"){ li.removeClass("themeStyle on"); li.addClass("themeStyle out"); }else{ li.removeClass("themeStyle out"); li.addClass("themeStyle on"); } }); }); </script> </div> <!-- 导航下拉缩小高度 --> <script type="text/javascript"> <!-- $(document).ready(function(){ $(window).scroll(function() { var top = $(".carousel-indicators,.visual-category-img").offset().top; //获取指定位置 var scrollTop = $(window).scrollTop(); //获取当前滑动位置 if(scrollTop > top){ //滑动到该位置时执行代码 $(".navbar").addClass("active"); }else{ $(".navbar").removeClass("active"); } }); }); $(function(){ var cubuk_seviye = $(document).scrollTop(); var header_yuksekligi = $('.navbar').outerHeight(); $(window).scroll(function() { var kaydirma_cubugu = $(document).scrollTop(); if (kaydirma_cubugu > header_yuksekligi){$('.navbar').addClass('gizle');} else {$('.navbar').removeClass('gizle');} if (kaydirma_cubugu > cubuk_seviye){$('.navbar').removeClass('sabit');} else {$('.navbar').addClass('sabit');} cubuk_seviye = $(document).scrollTop(); }); }); //--> </script> <!-- 鼠标滑过展开一级菜单/一级菜单可点击 --> <script type="text/javascript"> $(function () { $(".dropdown,.dropdown-submenu").mouseover(function () { $(this).addClass("open"); }); $(".dropdown,.dropdown-submenu").mouseleave(function(){ $(this).removeClass("open"); }) }); $(document).ready(function(){ var _width = $(window).width(); if(_width < 768){ $("#navbar a.toogle").click(function(){ event.preventDefault(); }); } }); </script> <!-- wow动态效果 --> <link rel="stylesheet" href="/template/default_visual/skin/css/animate.min.css" /> <script src="/template/default_visual/skin/js/wow.min.js"></script> <script> if (!(/msie [6|7|8|9]/i.test(navigator.userAgent))){ new WOW().init(); }; </script> <!-- 导航置顶CSS --> <style type="text/css"> .navbar { padding-right:0; padding-left:0;position:fixed; right:0; left:0; z-index:1030; border-radius:0; } @media (max-width: 768px) { #bootstrap-touch-slider {margin-top:62px;} #navbar {margin-top:62px;} .navbar>.container .navbar-brand, .navbar>.container-fluid .navbar-brand {margin-left:0px;} } @media (max-width: 468px) { #bootstrap-touch-slider {margin-top:62px;} } </style> <script> $(document).ready(function() { $("#owl-demo").owlCarousel({ items : 3, lazyLoad : true, navigation : true }); }); </script> <!-- Bootstrap core Javascript ================================================== --> <!-- Placed at the end of the document so the pages load faster --> <script src="/template/default_visual/skin/js/bootstrap.min.js"></script> <!-- Just to make our placeholder images work. Don't actually copy the next line! --> <script src="/template/default_visual/skin/js/holder.min.js"></script> <!-- IE10 viewport hack for Surface/desktop Windows 8 bug --> <script src="/template/default_visual/skin/js/ie10-viewport-bug-workaround.js"></script> <script src="/template/default_visual/skin/js/bootstrap-submenu.js"></script> <!--[if lt IE 9]><!--> <script src="/template/default_visual/skin/js/ie/html5shiv.min.js"></script> <script src="/template/default_visual/skin/js/ie/respond.min.js"></script> <![endif]--> <!-- 图片滚动 --> <link href="/js/carousel/css/owl.carousel.css" rel="stylesheet"> <script src="/js/carousel/owl.carousel.min.js"></script> <script> $(document).ready(function() { $("#owl-demo1").owlCarousel({ items : 3, lazyLoad : true, navigation : true }); }); </script> <script> $(document).ready(function() { $("#owl-demo-friendlink-logo").owlCarousel({ items : 3, lazyLoad : true, navigation : true }); }); </script> <!-- 幻灯 --> <script src="/template/default_visual/skin/js/slide/jquery.touchSwipe.min.js"></script> <script src="/template/default_visual/skin/js/slide/bootstrap-touch-slider.js"></script> <!-- 繁简切换 --> <script type="text/javascript" src="/js/common.js"></script> <!-- 左侧树形菜单 --> <link rel="stylesheet" href="/js/left_menu_list/left_menu_list.css"> <script src="/js/left_menu_list/left_menu_list.js"></script> <!-- 内容切换图片 --> <link href="/template/default_visual/skin/js/lightgallery/css/lightgallery.css" rel="stylesheet"> <script src="/template/default_visual/skin/js/lightgallery/js/lightgallery.min.js"></script> <script src="/template/default_visual/skin/js/lightgallery/js/lg-pager.min.js"></script> <script src="/template/default_visual/skin/js/lightgallery/js/lg-fullscreen.min.js"></script> <script src="/template/default_visual/skin/js/lightgallery/js/lg-zoom.min.js"></script> <script src="/template/default_visual/skin/js/lightgallery/js/lg-hash.min.js"></script> <script> lightGallery(document.getElementById('lightgallery')); </script> <!-- 内容文字大小 --> <script src="/template/default_visual/skin/js/c_tool.js"></script> <!-- 幻灯支持手势滑动 --> <script type="text/javascript"> $('#bootstrap-touch-slider').bsTouchSlider(); </script> </body> </html>