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</div> <div class="container-fluid clearfix layout_564394 text-center text-bold" style="font-size: 20px; color: rgb(0, 0, 0); margin-top: 30px; margin-bottom: 15px;"> <div class="column"> <div class="container clearfix layout_439253"> <div class="column"> <div class="column visual-conent-title"> <p class="content-title"> 外泌体LncRNA促进肿瘤细胞耐药性</p> <div class="clearfix"> </div> </div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_610181" style="margin-top: 0px;"> <div class="column"> <div class="container clearfix layout_148235 text-center text-bold" style="font-size: 20px; color: rgb(0, 0, 0);"> <div class="column"> <div class="hr"> </div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_369638 text-center" style="margin-top: 15px; margin-bottom: 15px;"> <div class="column"> <div class="container clearfix layout_13448"> <div class="column"> <div class="col-md-12 layout_455380"> <div class="col-md-2 column"> </div> <div class="col-md-8 column"> <div class="column visual-conent-author visual-inline-block"> <p class="content-author"> <span>作者：</span>admin</p> </div> <div class="column visual-conent-adddate visual-inline-block" style="padding-left: 15px; padding-right: 15px;"> <p class="content-adddate"> <span>添加时间：</span>2019-04-20 13:10:20</p> </div> <div class="column visual-conent-source visual-inline-block"> <p class="content-source"> <span>来源：</span>云序生物</p> </div> <div class="column visual-category-statistics visual-inline-block" style="padding-left: 15px;"> 浏览：<script src="/index.php?case=archive&act=view_js&aid=33"></script></div> </div> <div class="col-md-2 column"> </div> </div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_617573" style="margin-top: 15px; margin-bottom: 15px;"> <div class="column"> <div class="container clearfix layout_903271"> <div class="column"> <div class="column visual-category-title"> <div class="content_tools_box"> <p class="content_tools"> <a href="javascript:CallPrint('print');">打印本文</a> <a href="javascript:doZoom(14)">小</a> <a href="javascript:doZoom(18)">中</a> <a href="javascript:doZoom(20)">大</a> </p> <div class="clearfix"> </div> </div> </div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_43304" style="margin-top: 15px; margin-bottom: 15px;"> <div class="column"> <div class="container clearfix layout_784828"> <div class="column"> <div class="column visual-conent"> <p><strong>题目</strong>：Exosome-Transmitted lncARSR Promotes Sunitinib Resistance in Renal Cancer by Acting as a Competing Endogenous RNA</p><p><strong>期刊</strong>：Cancer Cell</p><p><strong>影响因子</strong>：27.41</p><p><strong>简介</strong>：本文阐述了疾病相关LncRNA参与肾癌耐药性及通过外泌体传播的生理机制。首先，作者通过高通量手段检测了野生型细胞和耐药型细胞中差异表达的LncRNA，并通过病人源性异种移植模型(PDX)鉴定到8条疑似致病LncRNA。将其中一条LncRNA-LncARSR (Activated in RCC with Sunitinib Resistance)敲除后，细胞耐药性显著增强。进一步研究表明LncARSR与肾癌细胞增殖、粘附等表型密切相关。作者研究发现，LncARSR主要存在于细胞外泌体中，并且耐药细胞外泌体LncRNA含量要远高于野生型细胞。作者随后通过RNA Pull Down实验证实核不均一性核糖核蛋白A2B1(hnRNPA2B1)负责包埋LncARSR进入外泌体。当提取耐药细胞外泌体孵育到野生型细胞后，野生型细胞胞内LncARSR含量增加，细胞耐药性增强。而胞内LncARSR主要发挥miRNA海绵功能，通过竞争性结合miRNA-34和miRNA-449，促进AXL和c-MET表达及下游STAT3、AKT、ERK信号通路的活化，最终导致舒尼替尼耐药性形成。</p><p style="text-align: center;"><img src="/html/upload/images/201904/15563523937502.png" width="960" height="394"/></p></div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_676599" style="margin-top: 15px; margin-bottom: 15px;"> <div class="column"> <div class="container clearfix layout_158624"> <div class="column"> <div class="hr"> </div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_667472"> <div class="column"> <div class="container clearfix layout_381979"> <div class="column"> <div class=" visual-conent-form"> </div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_886423" style="margin-top: 15px; margin-bottom: 5px;"> <div class="column"> <div class="container clearfix layout_390441"> <div class="column"> <div class="column visual-conent-page"> <div id="page"> <strong>上一篇</strong><a href="/index.php?case=archive&act=show&aid=32">大脑创伤外泌体中环状RNA变化的研究</a> <div class="blank10"> </div> <strong>下一篇</strong><a href="/index.php?case=archive&act=show&aid=34">肿瘤缺氧环境促进外泌体癌症LncRNA高表达</a> </div> </div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_402892" style="margin-top: 15px; margin-bottom: 15px;"> <div class="column"> <div class="container clearfix layout_939884"> <div class="column"> <div class="hr"> </div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_57479" style="margin-top: 15px; margin-bottom: 15px;"> <div class="column"> <div class="container clearfix layout_608164"> <div class="column"> <div class="column visual-conent-comment"> </div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_815628" style="margin-top: 15px; margin-bottom: 15px;"> <div class="column"> <div class="container clearfix layout_771703"> <div class="column"> <div class="hr"> </div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_275539" style="margin-top: 15px; margin-bottom: 15px;"> <div class="column"> <div class="container clearfix layout_875600"> <div class="column"> <div class="column visual-conent-relevant-list"> <h3> <a><a href='/index.php?case=tag&act=show&tag=%E5%A4%96%E6%B3%8C%E4%BD%93' target='_blank'>外泌体</a> <a href='/index.php?case=tag&act=show&tag=LncRNA' target='_blank'>LncRNA</a> <a href='/index.php?case=tag&act=show&tag=%E8%82%BF%E7%98%A4' target='_blank'>肿瘤</a> <a href='/index.php?case=tag&act=show&tag=%E8%80%90%E8%8D%AF' target='_blank'>耐药</a> <small>相关内容</small></a> </h3> <span>——</span> <hr class="featurette-divider" /> <div class="container list-container"> <div class="news-list list-border list-border-w"> <div class="list-date"> <span>21</span> <p> 2019-03</p> </div> <h4> <a title=""新宠"外泌体正式进入临床检验，路还有多远？" href="/index.php?case=archive&act=show&aid=65" 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0px 0px no-repeat; background-color:#999;} .izl-rmenu .btn-wangwang:hover{background-color:#444;} .izl-rmenu a.btn-wangwang,.izl-rmenu a.btn-wangwang:visited{background:url(/template/default_visual/skin/images/servers/metro_color/r_wangwang.png) 0px 0px no-repeat; background-color:#999; text-decoration:none; display:block;} .izl-rmenu .btn-skype{background:url(/template/default_visual/skin/images/servers/metro_color/r_skype.png) 0px 0px no-repeat; background-color:#999;} .izl-rmenu .btn-skype:hover{background-color:#444;} .izl-rmenu a.btn-skype,.izl-rmenu a.btn-skype:visited{background:url(/template/default_visual/skin/images/servers/metro_color/r_skype.png) 0px 0px no-repeat; background-color:#999; text-decoration:none; display:block;} .izl-rmenu .btn-web{background:url(/template/default_visual/skin/images/servers/metro_color/r_web.png) 0px 0px no-repeat; background-color:#999;} .izl-rmenu .btn-web:hover{background-color:#444;} .izl-rmenu a.btn-web,.izl-rmenu a.btn-web:visited{background:url(/template/default_visual/skin/images/servers/metro_color/r_web.png) 0px 0px no-repeat; background-color:#999; text-decoration:none; display:block;} .izl-rmenu .btn-top{background:url(/template/default_visual/skin/images/servers/metro_color/r_top.png) 0px 0px no-repeat; background-color:#999; display:none;} .izl-rmenu .btn-top:hover{background-color:#444;} </style> <script language="javascript" type="text/javascript"> $(function(){ var tophtml="<div id=\"izl_rmenu\" class=\"izl-rmenu\"><div class=\"sbtn btn-qq\"><div class=\"qq\"><a rel=\"nofollow\" target=\"_blank\" href=\"tencent://Message/?Uin=226976731&websiteName=http://www.ncell.com.cn=&Menu=yes\">客服一</a><br /><a rel=\"nofollow\" target=\"_blank\" href=\"tencent://Message/?Uin=525274299&websiteName=http://www.ncell.com.cn=&Menu=yes\">客服二</a></div></div><div class=\"sbtn btn-wx\"><img class=\"pic\" src=\"/html/upload/images/201904/15565910929476.png\" onclick=\"window.location.href=\'http:\'\"/></div><div class=\"sbtn btn-phone\"><div class=\"phone\">0592-5792117</div></div><div class=\"sbtn btn-top\"></div></div>"; $("#top").html(tophtml); $("#izl_rmenu").each(function(){ $(this).find(".btn-qq").mouseenter(function(){ $(this).find(".qq").fadeIn("fast"); }); $(this).find(".btn-qq").mouseleave(function(){ $(this).find(".qq").fadeOut("fast"); }); $(this).find(".btn-wx").mouseenter(function(){ $(this).find(".pic").fadeIn("fast"); }); $(this).find(".btn-wx").mouseleave(function(){ $(this).find(".pic").fadeOut("fast"); }); $(this).find(".btn-phone").mouseenter(function(){ $(this).find(".phone").fadeIn("fast"); }); $(this).find(".btn-phone").mouseleave(function(){ $(this).find(".phone").fadeOut("fast"); }); $(this).find(".btn-top").click(function(){ $("html, body").animate({ "scroll-top":0 },"fast"); }); }); var lastRmenuStatus=false; $(window).scroll(function(){//bug var _top=$(window).scrollTop(); if(_top>200){ $("#izl_rmenu").data("expanded",true); }else{ $("#izl_rmenu").data("expanded",false); } if($("#izl_rmenu").data("expanded")!=lastRmenuStatus){ lastRmenuStatus=$("#izl_rmenu").data("expanded"); if(lastRmenuStatus){ $("#izl_rmenu .btn-top").slideDown(); }else{ $("#izl_rmenu .btn-top").slideUp(); } } }); }); </script> <div id="top"></div><![endif]--> <!-- 短信 --> </div> <div class="servers-wap"> <link href="/template/default_visual/skin/css/wap/wap6.css" rel="stylesheet" /> <style type="text/css"> #plug-wrap { position: fixed; top: 0; left: 0; width: 100%; height: 100%; background: rgba(0, 0, 0, 0); z-index:800; } .top_bar { position:fixed; bottom:0; right:0px; z-index:900; -webkit-tap-highlight-color: rgba(0, 0, 0, 0); font-family: Helvetica, Tahoma, Arial, Microsoft YaHei, sans-serif; } .plug-menu { -webkit-appearance:button; display:inline-block; width:36px; height:36px; border-radius:36px; position: absolute; bottom:17px; right: 17px; z-index:999; box-shadow: 0 0 0 4px #FFFFFF, 0 2px 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