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</div> <div class="container-fluid clearfix layout_564394 text-center text-bold" style="font-size: 20px; color: rgb(0, 0, 0); margin-top: 30px; margin-bottom: 15px;"> <div class="column"> <div class="container clearfix layout_439253"> <div class="column"> <div class="column visual-conent-title"> <p class="content-title"> 肿瘤缺氧环境促进外泌体癌症LncRNA高表达</p> <div class="clearfix"> </div> </div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_610181" style="margin-top: 0px;"> <div class="column"> <div class="container clearfix layout_148235 text-center text-bold" style="font-size: 20px; color: rgb(0, 0, 0);"> <div class="column"> <div class="hr"> </div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_369638 text-center" style="margin-top: 15px; margin-bottom: 15px;"> <div class="column"> <div class="container clearfix layout_13448"> <div class="column"> <div class="col-md-12 layout_455380"> <div class="col-md-2 column"> </div> <div class="col-md-8 column"> <div class="column visual-conent-author visual-inline-block"> <p class="content-author"> <span>作者：</span>admin</p> </div> <div class="column visual-conent-adddate visual-inline-block" style="padding-left: 15px; padding-right: 15px;"> <p class="content-adddate"> <span>添加时间：</span>2019-04-08 13:28:32</p> </div> <div class="column visual-conent-source visual-inline-block"> <p class="content-source"> <span>来源：</span>云序生物</p> </div> <div class="column visual-category-statistics visual-inline-block" style="padding-left: 15px;"> 浏览：<script src="/index.php?case=archive&act=view_js&aid=34"></script></div> </div> <div class="col-md-2 column"> </div> </div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_617573" style="margin-top: 15px; margin-bottom: 15px;"> <div class="column"> <div class="container clearfix layout_903271"> <div class="column"> <div class="column visual-category-title"> <div class="content_tools_box"> <p class="content_tools"> <a href="javascript:CallPrint('print');">打印本文</a> <a href="javascript:doZoom(14)">小</a> <a href="javascript:doZoom(18)">中</a> <a href="javascript:doZoom(20)">大</a> </p> <div class="clearfix"> </div> </div> </div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_43304" style="margin-top: 15px; margin-bottom: 15px;"> <div class="column"> <div class="container clearfix layout_784828"> <div class="column"> <div class="column visual-conent"> <p><strong>题目</strong>：Hypoxic exosomes facilitate bladder tumor growth and development through transferring long non-coding RNA-UCA1</p><p><strong>期刊</strong>：Molecular Cell</p><p><strong>影响因子</strong>：7.78</p><p><strong>简介</strong>：为克服实体肿瘤的恶性缺氧微环境，肿瘤细胞会分泌大量含非编码RNA的外泌体，促进肿瘤的发生和转移。研究人员选取膀胱癌5637细胞系作为实验供体组，其具有LncRNA-UCA1（尿路上皮癌相关1型LncRNA）高表达的特点；膀胱癌UMUC2细胞系作为实验受体组，其具有LncRNA-UCA1低表达的特点。通过透射电子显微镜、纳米粒子跟踪分析和蛋白质印迹分析分离并鉴定了在常氧及缺氧条件下5637细胞分泌的外泌体。将这些外泌体与UMUC2细胞共培养，发现来自5637细胞分离的缺氧外泌体会促进UMUC2细胞增殖、迁移和侵袭。与常氧状态培养分离外泌体相比，5637细胞系的缺氧外泌体中LncRNA-UCA1表达水平较高。此外，缺氧外泌体LncRNA-UCA1可以在体外和体内通过上皮间质转化促进肿瘤生殖生长。除此之外，膀胱癌患者血清外泌体中LncRNA-UCA1的表达水平显著高于健康对照组。本文证实缺氧膀胱癌细胞通过分泌富含致癌性LncRNA-UCA1的外泌体到肿瘤微环境中，促进肿瘤的生长和发育。并且，人血清外泌体LncRNA-UCA1具有作为膀胱癌诊断生物标志物的可能性。</p><p style="text-align: center;"><img src="/html/upload/images/201904/15563526289517.png" width="833" height="679"/></p></div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_676599" style="margin-top: 15px; margin-bottom: 15px;"> <div class="column"> <div class="container clearfix layout_158624"> <div class="column"> <div class="hr"> </div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_667472"> <div class="column"> <div class="container clearfix layout_381979"> <div class="column"> <div class=" visual-conent-form"> </div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_886423" style="margin-top: 15px; margin-bottom: 5px;"> <div class="column"> <div class="container clearfix layout_390441"> <div class="column"> <div class="column visual-conent-page"> <div id="page"> <strong>上一篇</strong><a href="/index.php?case=archive&act=show&aid=33">外泌体LncRNA促进肿瘤细胞耐药性</a> <div class="blank10"> </div> <strong>下一篇</strong><a href="/index.php?case=archive&act=show&aid=35">脂肪来源的干细胞分泌外泌体可减轻脂肪炎症和肥胖现象</a> </div> </div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_402892" style="margin-top: 15px; margin-bottom: 15px;"> <div class="column"> <div class="container clearfix layout_939884"> <div class="column"> <div class="hr"> </div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_57479" style="margin-top: 15px; margin-bottom: 15px;"> <div class="column"> <div class="container clearfix layout_608164"> <div class="column"> <div class="column visual-conent-comment"> </div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_815628" style="margin-top: 15px; margin-bottom: 15px;"> <div class="column"> <div class="container clearfix layout_771703"> <div class="column"> <div class="hr"> </div> </div> </div> </div> </div> <div class="container-fluid clearfix layout_275539" style="margin-top: 15px; margin-bottom: 15px;"> <div class="column"> <div class="container clearfix layout_875600"> <div class="column"> <div class="column visual-conent-relevant-list"> <h3> <a><small>相关内容</small></a> </h3> <span>——</span> <hr class="featurette-divider" /> <div class="container list-container"> <div class="news-list list-border list-border-w"> <div class="list-date"> <span>08</span> <p> 2019-04</p> </div> <h4> <a title="肿瘤缺氧环境促进外泌体癌症LncRNA高表达" href="/index.php?case=archive&act=show&aid=34" target="_blank">肿瘤缺氧环境促进外泌体癌症LncRNA高</a> </h4> <p> 本文证实缺氧膀胱癌细胞通过分泌富含致癌性LncRNA-UCA1的外泌体到肿瘤微环境中，促进肿瘤的生长和发育。并且，人血清外泌体LncRNA-UCA1具有作为膀胱癌诊断生物标志物的可能性。… <a href="/index.php?case=archive&act=show&aid=34" target="_blank">[了解更多]</a> </p> </div> </div> <div class="clearfix"> </div> </div> </div> </div> </div> </div> </div> <div class="view-html"> <div class="container-fluid clearfix layout_971667" style="padding-top: 60px; padding-bottom: 60px; background-color: rgb(51, 51, 51); color: rgb(255, 255, 255);"> <div class="column"> <div class="container clearfix layout_976890 text-bold" style="font-size: 20px; padding-top: 20px; padding-bottom: 20px;"> <div class="column"> 厦门恩赛尔生物科技有限公司位于国家级企业孵化基地海沧生物医药产业园，参照GMP标准建设有完善的研发生产实验室并通过厦门市食品药品质量检查研究院依据国家标准GB50457-2008的洁净级别检测，团队汇聚大帮技术精湛的博士、硕士人员及外籍科学家，并由多名“千人计划”专家作为技术顾问，同时兼具遗传咨询师、系统架构师、注册审核员等各类人才，具备专业的科学研究和服务咨询能力。 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placeholder="请输入查询信息！"> <span class="input-group-btn"> <button class="btn btn-default" name='submit' type="submit">搜索</button> </span> </div> </div> <div class="col-lg-1"></div> </form> </div> </div> </div> </div> <!-- search end --> <!-- shopping 购物车 --> <div class="modal fade bs-example-modal-lg-shopping" tabindex="-1" role="dialog" aria-labelledby="mySmallModalLabel"> <div class="modal-dialog modal-sm"> <div class="modal-content"> </div> </div> </div> <!-- s/shopping 购物车 --> <div class="servers"> <!--[if (gte IE 7)|!(IE)]><!--> <!-- 在线客服 --> <style type="text/css"> .izl-rmenu{position:fixed; left:0; margin-right:20px; bottom:0px; padding-bottom:0px; z-index:999; } .izl-rmenu .sbtn{width:72px; height:73px; margin-bottom:1px; cursor:pointer; position:relative;} .izl-rmenu .btn-qq{background:url(/template/default_visual/skin/images/servers/metro_color/r_qq.png) 0px 0px no-repeat; background-color:#999;color:#FFF;} .izl-rmenu .btn-qq:hover{background-color:#444;color:#FFF;} .izl-rmenu 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.btn-ali{background:url(/template/default_visual/skin/images/servers/metro_color/r_ali.png) 0px 0px no-repeat; background-color:#999;} .izl-rmenu .btn-ali:hover{background-color:#444;} .izl-rmenu a.btn-ali,.izl-rmenu a.btn-ali:visited{background:url(/template/default_visual/skin/images/servers/metro_color/r_ali.png) 0px 0px no-repeat; background-color:#999; text-decoration:none; display:block;} .izl-rmenu .btn-wangwang{background:url(/template/default_visual/skin/images/servers/metro_color/r_wangwang.png) 0px 0px no-repeat; background-color:#999;} .izl-rmenu .btn-wangwang:hover{background-color:#444;} .izl-rmenu a.btn-wangwang,.izl-rmenu a.btn-wangwang:visited{background:url(/template/default_visual/skin/images/servers/metro_color/r_wangwang.png) 0px 0px no-repeat; background-color:#999; text-decoration:none; display:block;} .izl-rmenu .btn-skype{background:url(/template/default_visual/skin/images/servers/metro_color/r_skype.png) 0px 0px no-repeat; background-color:#999;} .izl-rmenu .btn-skype:hover{background-color:#444;} .izl-rmenu a.btn-skype,.izl-rmenu a.btn-skype:visited{background:url(/template/default_visual/skin/images/servers/metro_color/r_skype.png) 0px 0px no-repeat; background-color:#999; text-decoration:none; display:block;} .izl-rmenu .btn-web{background:url(/template/default_visual/skin/images/servers/metro_color/r_web.png) 0px 0px no-repeat; background-color:#999;} .izl-rmenu .btn-web:hover{background-color:#444;} .izl-rmenu a.btn-web,.izl-rmenu a.btn-web:visited{background:url(/template/default_visual/skin/images/servers/metro_color/r_web.png) 0px 0px no-repeat; background-color:#999; text-decoration:none; display:block;} .izl-rmenu .btn-top{background:url(/template/default_visual/skin/images/servers/metro_color/r_top.png) 0px 0px no-repeat; background-color:#999; display:none;} .izl-rmenu .btn-top:hover{background-color:#444;} </style> <script language="javascript" type="text/javascript"> $(function(){ var tophtml="<div id=\"izl_rmenu\" class=\"izl-rmenu\"><div class=\"sbtn btn-qq\"><div class=\"qq\"><a rel=\"nofollow\" target=\"_blank\" href=\"tencent://Message/?Uin=226976731&websiteName=http://www.ncell.com.cn=&Menu=yes\">客服一</a><br /><a rel=\"nofollow\" target=\"_blank\" href=\"tencent://Message/?Uin=525274299&websiteName=http://www.ncell.com.cn=&Menu=yes\">客服二</a></div></div><div class=\"sbtn btn-wx\"><img class=\"pic\" src=\"/html/upload/images/201904/15565910929476.png\" onclick=\"window.location.href=\'http:\'\"/></div><div class=\"sbtn btn-phone\"><div class=\"phone\">0592-5792117</div></div><div class=\"sbtn btn-top\"></div></div>"; $("#top").html(tophtml); $("#izl_rmenu").each(function(){ $(this).find(".btn-qq").mouseenter(function(){ $(this).find(".qq").fadeIn("fast"); }); $(this).find(".btn-qq").mouseleave(function(){ $(this).find(".qq").fadeOut("fast"); }); $(this).find(".btn-wx").mouseenter(function(){ $(this).find(".pic").fadeIn("fast"); }); $(this).find(".btn-wx").mouseleave(function(){ $(this).find(".pic").fadeOut("fast"); }); $(this).find(".btn-phone").mouseenter(function(){ $(this).find(".phone").fadeIn("fast"); }); $(this).find(".btn-phone").mouseleave(function(){ $(this).find(".phone").fadeOut("fast"); }); $(this).find(".btn-top").click(function(){ $("html, body").animate({ "scroll-top":0 },"fast"); }); }); var lastRmenuStatus=false; $(window).scroll(function(){//bug var _top=$(window).scrollTop(); if(_top>200){ $("#izl_rmenu").data("expanded",true); }else{ $("#izl_rmenu").data("expanded",false); } if($("#izl_rmenu").data("expanded")!=lastRmenuStatus){ lastRmenuStatus=$("#izl_rmenu").data("expanded"); if(lastRmenuStatus){ $("#izl_rmenu .btn-top").slideDown(); }else{ $("#izl_rmenu .btn-top").slideUp(); } } }); }); </script> <div id="top"></div><![endif]--> <!-- 短信 --> </div> <div class="servers-wap"> <link href="/template/default_visual/skin/css/wap/wap6.css" rel="stylesheet" /> <style type="text/css"> #plug-wrap { position: fixed; top: 0; left: 0; width: 100%; height: 100%; background: rgba(0, 0, 0, 0); z-index:800; } .top_bar { position:fixed; bottom:0; right:0px; z-index:900; -webkit-tap-highlight-color: rgba(0, 0, 0, 0); font-family: Helvetica, Tahoma, Arial, Microsoft YaHei, sans-serif; } .plug-menu { -webkit-appearance:button; display:inline-block; width:36px; height:36px; border-radius:36px; position: absolute; bottom:17px; right: 17px; z-index:999; box-shadow: 0 0 0 4px #FFFFFF, 0 2px 5px 4px rgba(0, 0, 0, 0.25); -webkit-transition: -webkit-transform 200ms; -webkit-transform:rotate(1deg); color:#fff; background-image:url('/template/default_visual/skin/images/wao/plug.png'); background-repeat: no-repeat; -webkit-background-size: 80% auto; background-size: 80% auto; background-position: center center; } .plug-menu:before { font-size:20px; margin:9px 0 0 9px; } .plug-menu:checked { -webkit-transform:rotate(135deg); } .top_menu>li { width: 32px; height:32px; border-radius:32px; box-shadow: 0 0 0 3px #FFFFFF, 0 2px 5px 3px rgba(0, 0, 0, 0.25); position:absolute; bottom:0; right:0; margin-bottom: 20px; margin-right:20px; z-index:900; -webkit-transition: -webkit-transform 200ms; } .top_menu>li a { color:#fff; font-size:20px; display: block; height: 100%; line-height: 33px; text-align: center; } .top_menu>li>a label{ display:none; } .top_menu>li a img { display: block; width: 22px; height: 22px; text-indent: -999px; position: absolute; top: 50%; left: 50%; margin-top: -11px; margin-left: -11px; } .top_menu>li.on:nth-of-type(1) { -webkit-transform: translate(-0, -100px) rotate(720deg); } .top_menu>li.on:nth-of-type(2) { -webkit-transform: translate(-47px, -81px) rotate(720deg); } .top_menu>li.on:nth-of-type(3) { -webkit-transform: translate(-81px, -45px) rotate(720deg); } .top_menu>li.on:nth-of-type(4) { -webkit-transform: translate(-100px, 0) rotate(720deg); } #sharemcover { position: fixed; top: 0; left: 0; width: 100%; height: 100%; background: rgba(0, 0, 0, 0.7); display: none; z-index: 20000; } #sharemcover img { position: fixed; right: 18px; top: 5px; width: 260px; height: 180px; z-index: 20001; border:0; } </style> <div class="top_bar" style="-webkit-transform:translate3d(0,0,0)"> <nav> <ul id="top_menu" class="top_menu"> <input type="checkbox" id="plug-btn" class="plug-menu themeStyle" style="background-image:url('/template/default_visual/skin/images/wap/plug.png');border:0px;"> <li class="themeStyle out" style="background:"> <a href="tel:0592-5792117"><img src="/template/default_visual/skin/images/wap/plugmenu1.png"><label>电 话</label></a> </li> <li class="themeStyle out" style="background:"> <a href="sms:13599994885"><img src="/template/default_visual/skin/images/wap/plugmenu3.png"><label>短信</label></a> </li> <li class="themeStyle out" style="background:"> <a href="mqqwpa://im/chat?chat_type=wpa&uin=226976731&version=1&src_type=web&web_src=http://www.ncell.com.cn" id="btn_fenxiang"><img src="/template/default_visual/skin/images/wap/plugmenu5.png"><label>QQ号码</label></a> </li> <li class="themeStyle out" style="background:"> <a href="/index.php?case=guestbook&act=index"><img src="/template/default_visual/skin/images/wap/plugmenu6.png"><label>留言</label></a> </li> </ul> </nav> </div> <div id="plug-wrap" style="display: none;" ></div> <script> $(function(){ $(".plug-menu").click(function(){ var li = $(this).parents('ul').find('li'); if(li.attr("class") == "themeStyle on"){ li.removeClass("themeStyle on"); li.addClass("themeStyle out"); }else{ li.removeClass("themeStyle out"); li.addClass("themeStyle on"); } }); }); </script> </div> <!-- 导航下拉缩小高度 --> <script type="text/javascript"> <!-- $(document).ready(function(){ $(window).scroll(function() { var top = $(".carousel-indicators,.visual-category-img").offset().top; //获取指定位置 var scrollTop = $(window).scrollTop(); //获取当前滑动位置 if(scrollTop > top){ //滑动到该位置时执行代码 $(".navbar").addClass("active"); }else{ $(".navbar").removeClass("active"); } }); }); $(function(){ var cubuk_seviye = $(document).scrollTop(); var header_yuksekligi = $('.navbar').outerHeight(); $(window).scroll(function() { var kaydirma_cubugu = $(document).scrollTop(); if (kaydirma_cubugu > header_yuksekligi){$('.navbar').addClass('gizle');} else {$('.navbar').removeClass('gizle');} if (kaydirma_cubugu > cubuk_seviye){$('.navbar').removeClass('sabit');} else {$('.navbar').addClass('sabit');} cubuk_seviye = $(document).scrollTop(); }); }); //--> </script> <!-- 鼠标滑过展开一级菜单/一级菜单可点击 --> <script type="text/javascript"> $(function () { $(".dropdown,.dropdown-submenu").mouseover(function () { $(this).addClass("open"); }); $(".dropdown,.dropdown-submenu").mouseleave(function(){ $(this).removeClass("open"); }) }); $(document).ready(function(){ var _width = $(window).width(); if(_width < 768){ $("#navbar a.toogle").click(function(){ event.preventDefault(); }); } }); </script> <!-- wow动态效果 --> <link rel="stylesheet" href="/template/default_visual/skin/css/animate.min.css" /> <script src="/template/default_visual/skin/js/wow.min.js"></script> <script> if (!(/msie [6|7|8|9]/i.test(navigator.userAgent))){ new WOW().init(); }; </script> <!-- 导航置顶CSS --> <style type="text/css"> .navbar { padding-right:0; padding-left:0;position:fixed; right:0; left:0; z-index:1030; border-radius:0; } @media (max-width: 768px) { #bootstrap-touch-slider {margin-top:62px;} #navbar {margin-top:62px;} .navbar>.container .navbar-brand, .navbar>.container-fluid .navbar-brand {margin-left:0px;} } @media (max-width: 468px) { #bootstrap-touch-slider {margin-top:62px;} } </style> <script> $(document).ready(function() { $("#owl-demo").owlCarousel({ items : 3, lazyLoad : true, navigation : true }); }); </script> <!-- Bootstrap core Javascript ================================================== --> <!-- Placed at the end of the document so the pages load faster --> <script src="/template/default_visual/skin/js/bootstrap.min.js"></script> <!-- Just to make our placeholder images work. Don't actually copy the next line! --> <script src="/template/default_visual/skin/js/holder.min.js"></script> <!-- IE10 viewport hack for Surface/desktop Windows 8 bug --> <script src="/template/default_visual/skin/js/ie10-viewport-bug-workaround.js"></script> <script src="/template/default_visual/skin/js/bootstrap-submenu.js"></script> <!--[if lt IE 9]><!--> <script src="/template/default_visual/skin/js/ie/html5shiv.min.js"></script> <script src="/template/default_visual/skin/js/ie/respond.min.js"></script> <![endif]--> <!-- 图片滚动 --> <link href="/js/carousel/css/owl.carousel.css" rel="stylesheet"> <script src="/js/carousel/owl.carousel.min.js"></script> <script> $(document).ready(function() { $("#owl-demo1").owlCarousel({ items : 3, lazyLoad : true, navigation : true }); }); </script> <script> $(document).ready(function() { $("#owl-demo-friendlink-logo").owlCarousel({ items : 3, lazyLoad : true, navigation : true }); }); </script> <!-- 幻灯 --> <script src="/template/default_visual/skin/js/slide/jquery.touchSwipe.min.js"></script> <script src="/template/default_visual/skin/js/slide/bootstrap-touch-slider.js"></script> <!-- 繁简切换 --> <script type="text/javascript" src="/js/common.js"></script> <!-- 左侧树形菜单 --> <link rel="stylesheet" href="/js/left_menu_list/left_menu_list.css"> <script src="/js/left_menu_list/left_menu_list.js"></script> <!-- 内容切换图片 --> <link href="/template/default_visual/skin/js/lightgallery/css/lightgallery.css" rel="stylesheet"> <script src="/template/default_visual/skin/js/lightgallery/js/lightgallery.min.js"></script> <script src="/template/default_visual/skin/js/lightgallery/js/lg-pager.min.js"></script> <script src="/template/default_visual/skin/js/lightgallery/js/lg-fullscreen.min.js"></script> <script src="/template/default_visual/skin/js/lightgallery/js/lg-zoom.min.js"></script> <script src="/template/default_visual/skin/js/lightgallery/js/lg-hash.min.js"></script> <script> lightGallery(document.getElementById('lightgallery')); </script> <!-- 内容文字大小 --> <script src="/template/default_visual/skin/js/c_tool.js"></script> <!-- 幻灯支持手势滑动 --> <script type="text/javascript"> $('#bootstrap-touch-slider').bsTouchSlider(); </script> </body> </html>